The major residential push will bring affordable and market homes, student accommodation and co-living to the site between Queen Elizabeth Olympic Park and Westfield Stratford City.
Plans submitted to Newham Council also include a new park, shops and public paths to Stratford station.
Subject to planning, construction is due to start in 2028 and run for around three years.
Stratford Cross forms part of the Impact Partnership joint venture between Lendlease and The Crown Estate, which is targeting up to 9,000 homes across the UK in its first wave of developments.
The latest scheme will shift the emphasis at Stratford Cross towards housing after earlier phases established the area as a commercial, education and cultural hub.
Existing buildings include the Turing Building, where Arden University recently signed for 94,000 sq ft of space.
Development director Jason Oliver said: “Stratford has evolved into one of London’s most dynamic destinations for culture, education, innovation and business.
“This final phase is about building on that success and creating a neighbourhood where people can live alongside the workplaces, institutions and attractions that have helped establish Stratford Cross as a unique part of east London.”
