6 Best Wrinkle Fillers, Tested & Recommended by Dermatologists

Think the only way to address deep wrinkles is with a needle? Turns out, some of the best wrinkle fillers require neither an appointment nor a syringe—not to mention, they won’t cause swelling or bruising. “Topical wrinkle fillers are skin care products designed to temporarily plump and smooth the appearance of fine lines and wrinkles,” says Whitney Hovenic, MD, a board-certified dermatologist, Mohs surgeon, and cofounder of sunscreen brand Spooge. Despite the name, these creams, gels, or serums are “very different from injectable dermal fillers,” she says. Instead of adding volume beneath the skin, as the likes of Botox and Radiesse would do, these topical creams and serums hydrate the surface of the skin to create a fuller, more supple appearance. With so many options to choose from, how do you know if topical fillers are right for your wrinkles?

“Topical wrinkle fillers are best for someone who is noticing early signs of aging or wants a noninvasive way to make fine lines look softer,” Dr. Hovenic says. “They tend to work particularly well on superficial lines that become more noticeable when the skin is dry or dehydrated, including fine lines around the eyes, mouth, and forehead.” As a bonus, they come in clutch as makeup primers, hydrating and smoothing the skin before foundation is even applied. We tested a handful of options below, including our top pick, the Dr. Dennis Gross DRx BioRejuvenation Serum to soften creases and plump skin. We also found a supreme drugstore option, L’Oréal Revitalift Volume Filler Daily Volumizing Moisturizer to help decrease the appearance of volume loss. Ahead, find more topical wrinkle fillers dermatologists recommend for deep wrinkles, instant results, and more.

Our top wrinkle fillers

• Best Overall: Dr. Dennis Gross DRx BioRejuvenation Serum, $89
• Best for Deep Wrinkles: Strivectin Anti-Wrinkle Peptide Plump Line Filling Bounce Serum $78
• Best for Instant Results: L’Oréal Revitalift Volume Filler Daily Volumizing Moisturizer, $15
• Best for Eyes: No. 7 Future Renew Damage Reversal Eye Serum, $18
• Best for Lips: Alastin HA Immerse Serum, $134
• Best for Sensitive Skin: Andalou Naturals Deep Wrinkle Dermal Filler, $21

Best Overall: Dr. Dennis Gross DRx BioRejuvenation Serum

Dr. Dennis Gross’s Fill + Repair Serum has been a Glamour editor favorite since its 2023 launch. But when the brand debuted its DRx BioRejuvenation Serum in 2026, we (and our wrinkles) had to take notice. While most topical wrinkle fillers temporarily plump the skin for a firmer, smoother appearance (not a bad thing!), this formula works somewhat differently. Its star ingredient, collagen amino acids, can actually absorb into the skin, which isn’t true of topical collagen. The idea: to supply the skin with the building blocks it needs to produce more collagen on its own, becoming firmer, more elastic, and more resilient over time. The amino acids are paired with a trio of bioavailable actives—glutathione, niacinamide, and adenosine—that bolster the skin’s reparative processes. Overall, the formula was designed to soften fine lines and wrinkles while also smoothing specific areas that tend to sag with age—think nasolabial folds, jowls, neck, and jawline.

Best for Deep Wrinkles: Strivectin Anti-Wrinkle Peptide Plump Line Filling Bounce Serum

According to Alexandra Haskin, MD, a board-certified dermatologist in NYC, “This is a nicely formulated topical wrinkle filler because it contains ingredients that stimulate immediate plumping while also promoting long-term collagen production.” Those ingredients include humectants for immediate hydration and deep-wrinkle softening, plus a peptide complex said to stimulate collagen and elastin production over time. “Its silicone and silica-containing ingredients are also great for improving surface texture and reducing the appearance of crepey skin,” Dr. Haskin says.

Best for Instant Results: L’Oréal Revitalift Volume Filler Moisturizer

“What makes the L’Oréal Revitalift Volume Filler Moisturizer appealing for more immediate results is its combination of hydration and surface-smoothing ingredients,” says Dr. Hovenic. “It contains glycerin and sodium hyaluronate, a form of hyaluronic acid, which help attract and retain water in the skin. That boost in hydration can temporarily make fine lines appear less noticeable and give the skin a plumper look.” The formula also contains dimethicone, she says, which helps smooth the skin’s surface and can create a softer, more even finish. “I would think of the ‘instant’ benefit as primarily a hydrating and smoothing effect rather than an actual change to the underlying wrinkle,” she says—but that hydration adds up. “With continued use, keeping the skin consistently hydrated can also improve its overall texture and appearance,” Dr. Hovenic says.

Best for Eyes: No.7 Future Renew Damage Reversal Eye Serum

Dr. Haskin is quick to recommend this budget-friendly brand to patients. And though she notes that the eye cream doesn’t have as fast of a plumping effect as some other topical wrinkle fillers, its ingredients pay off in the long run to minimize fine lines around the eyes. “This is a great adjunct to an eye antiaging routine because it uses the brand’s specific peptide blend to boost collagen and cellular repair,” she says. “It also has many hydrating ingredients, including glycerin, hyaluronic acid, and shea butter.” According to Dr. Hovenic, “In an eye serum, hydration is particularly valuable because simply improving the skin’s water content can make small lines look softer and the area appear smoother and more refreshed. I also like seeing niacinamide in this type of formula because it has evidence supporting improvements in fine lines, pigmentation, and overall skin texture.” Plus, it’s user-friendly: Dr. Haskin has tried the product herself and was impressed with its “smooth, lightweight application.”

Best for Lips: Alastin HA Immerse Serum

A dermatologist favorite, this product penetrates deep into the skin, increasing its hyaluronic acid levels to support long-term hydration and plumping. And while facial serums are most commonly used, well, on the face, don’t forget that the skin on the lips needs some TLC too. “I’m a big supporter of using facial hyaluronic acid serums on the lips, especially at bedtime for added moisture retention,” Dr. Haskin says. “This Alastin HA serum is perfect for this purpose. I use it on my lips and entire face, especially during the dry winter months.” With multiple forms of hyaluronic acid, the product may encourage even higher moisture-binding capacity in the skin, which is especially valuable for lips. “The lips are particularly susceptible to water loss, which can exacerbate the appearance of aging in mature skin,” she says. “For the lips, this product can provide an immediate hydrated appearance and soften any visible lip lines.”

Best for Sensitive Skin: Andalou Naturals Deep Wrinkle Dermal Filler

“One ingredient that stands out to me in the Andalou Naturals Deep Wrinkle Dermal Filler is bakuchiol,” Dr. Hovenic says. “Bakuchiol has become a popular alternative for people who want some of the visible antiaging benefits associated with retinoids but may have difficulty tolerating retinol. In one randomized study, bakuchiol and retinol both improved wrinkles and hyperpigmentation, while the bakuchiol group reported less scaling and stinging.” The formula also includes hydrating and soothing ingredients such as aloe, allantoin, and sodium hyaluronate, which she says can plump and soften the look of fine lines. “That said, I would add an important caveat for truly sensitive skin: This particular product is not fragrance-free,” she says. “I would recommend patch-testing first and discontinuing use if you notice burning, persistent redness, or irritation.”

Wrinkle fillers we tried but did not include

• Peter Thomas Roth Peptide Skinjection Fill + Fix Under-Eye Cream was another contender for its impressive instant-smoothing effects. The silicone-based formula can visibly tighten and smooth fine lines in minutes, and Glamour contributor Taryn Brooke loved using it as a makeup primer when she wanted an especially flawless finish. We ultimately cut it from the list because the application requires a little more patience and precision than some of our other picks.
• RoC Retinol Correction Deep Wrinkle Filler has been a favorite of Glamour senior commerce editor Jenifer Calle, who says the retinol-infused cream significantly reduced the appearance of forehead lines with use just once or twice a week. We ultimately cut it from the list because retinol can irritate some skin types, making it a less universally approachable option for those looking for a wrinkle filler.
• Lawless Forget the Filler Skin-Plumping Line-Smoothing Perfecting Cream was another standout for its ability to plump and smooth fine lines while creating an ideal canvas for makeup. Glamour commerce writer Alanna Martine Kilkeary especially loved its peptide-packed formula and noticed a visible difference in her forehead lines after several weeks of use. We ultimately cut it from the list because it’s not as widely accessible as some of our other picks.